Some personal anecdotes from early neutrino physics involving Fred Reines, Ray Davis, John Bahcall and others will be given. This will be followed by a discussion of neutrino-less double beta decay and the status and perspectives of the CUORE double-beta decay experiment, as well as a CUORE progress report. Of particular interest is the fact that imposing coincidence requirements on data from the CUORICINO experiment resulted in a significant body of zero-background data. This technique could result in very exciting potential sensitivity for CUORE. The first tower of CUORE (CUORE-0) will be operational in early 2012. CUORE is designed to probe the inverted hierarchy region of neutrino mass, and will be on line in 2014. This is a very challenging experiment that utilizes cryogenic techniques; however, the success of the CUORICINO experiment gives encouragement that CUORE will potentially deliver exciting results.