Abstract: Unitarity of the Cabibbo-Kobayashi-Maskawa (CKM) quark mixing matrix is one of the cornerstones of the Standard Model.  The unitarity constraint that involves the top-row matrix elements, $|V_{ud}|^2+|V_{us}|^2+|V_{ub}|^2=1$ is particularly important because all elements are measured very precisely permitting a test at the 0.01\% level. At this accuracy, $V_{ub}\sim10^{-3}$ is irrelevant, and the unitarity constraint reduces to the two-flavor Cabibbo unitarity pattern with a single Cabibbo angle $\theta_C$ and $V_{ud}=\cos\theta_C$ and $V_{us}$. At present, a mild deficit is observed, $|V_{ud}|^2+|V_{us}|^2=0.9985(7)$. As such, this deficit may suggest some new physics, but to make this claim, all Standard Model ingredients must be firmly under control. I review these ingredients across theory and experiment and review the most recent developments.