Abstract: Multi-parton interactions are a fascinating phenomenon that occur in almost every high-energy hadron–hadron collision, yet are remarkably difficult to study quantitatively. In this talk, I’ll present a strategy to optimally disentangle multi-parton interactions from the primary scattering in a collision. That strategy enables probes of multi-parton interactions that are significantly beyond the state of the art, including their characteristic momentum scale, the interconnection between primary and secondary scatters, and the pattern of three and potentially even more simultaneous hard scatterings. This opens a path to powerful new constraints on multi-parton interactions for LHC phenomenology and to the investigation of their rich field-theoretical structure.