In the Standard Model of Particle Physics there are 28 fundamental constants. Theoretically they are not understood. I will discuss these constants, which are mostly mass parameters.Astrophysical experiments indicate that the finestructure constant depends on time. In this case Grand Unification implies a time variation of the QCD scale. Thus the masses of the atomic nuclei and their magnetic moments will vary slowly in cosmological time.I proposed an experiment, which is currently carried out by Prof. Haensch at the MPQ in Munich and his group. The results indicate a time dependence of the QCD scale. An astrophysics experiment at the VLT in Chile gives a similar result.