Abstract: In the last decade, it has become clear that many exoplanets orbit stars that also have one or more stellar companions. In this context, high-resolution imaging at large ground-based telescopes plays a key role in helping to develop robust statistics concerning the properties of such systems. The current status of these efforts will be reviewed. Because planet radii are inferred from stellar properties, deriving correct radii of exoplanets in binary stars relies on having high-precision magnitude difference measures of the stellar companions in these systems, a quantity that has often been difficult to obtain in high-resolution imaging. Looking toward the future, new ground-based instrumentation will be needed to overcome this difficulty and make further progress. Some leading ideas for this will be discussed.