Radiotherapy (RT) is one of the most frequently used methods for cancer treatment. Despite remarkable advancements, the dose tolerances of healthy tissues remain the main limitation in RT. Therefore, finding novel RT approaches that allow increasing healthy tissue resistance is the major challenge of RT. With this aim, my research is related to the development of hadron minibeam radiation therapy, an innovative RT approach that combines the inherent physical and biological advantages of hadron beams with the healthy tissue preservation observed when irradiated with submillimetric spatially fractionated beams. In this seminar, I will present my research in medical physics (Monte Carlo simulations, experimental dosimetry) for the assessment of the clinical potential of this innovative approach.