The fifty year anniversary of the Burbidge, Burbidge, Fowler and Hoyle paper \"Synthesis of the Elements in Stars\" has renewed interest in Nuclear Astrophysics. I will describe my own work a few years earlier still ( both successes and failures) and the efforts at Cal.Tech. in 1951. I will mention the importance of the 1953 Astrophysics summer school in Ann Arbor for much future work including my own paper on the \"Initial Mass Function\" for stars. Fir biophysics I will recall theoretical models for the \"Neuromuscular Junction\", the simplest of all synapses in animals, as they developed over a few decades. This is an example of proceeding from two-dimensional models to more realistic three-dimensional ones. I will finish on the application of Statistics to Maedical Research, including \"Meta-analysis\" on drugs for Asthma and Hormone Replacement Therapy for Menopause.