Abstract: The Fermi Large Area Telescope is a leading space-born gamma-ray detector that has been exploring the gamma-ray sky since 2008. Together with many other discoveries, it contributed to establish as particle accelerators several populations of binary systems with very different astrophysical properties. Non-accreting pulsar binaries, novae, massive stars with colliding winds or jetted microquasars are some of those systems, though only a few of them have been detected. In this talk, we will discuss the advantages and difficulties of using Fermi-LAT to explore binaries, and finally review recent studies on such systems - including new detections and future perspectives.