Abstract: In ab-initio electronic structure simulations, fermion-to-qubit mappings represent the initial encoding step of the fermionic problem into qubits. Here, a physically-inspired method is presented for constructing mappings that significantly simplify entanglement requirements when simulating states of interest. The presence of electronic excitations drives the construction of the mappings, reducing correlations for target states in the qubit space. Ultimately, ground state simulation of small molecules offers enhanced performance when compared to prior research employing conventional mappings, both in the frameworks of quantum computing and tensor networks.