We will discuss semiholography, a new non-perturbative effective framework, in the context of various aspects of QCD dynamics at large N, and show that it can incorporate both weakly coupled UV dynamics and strongly coupled IR dynamics in a consistent manner, and allow us to obtain real-time physics directly. Applications to physics of heavy-ion collisions, and also for new models of hadrons and exotic states will be emphasized. We will also sketch a derivation of this framework via matching Wilsonian RG flow for UV physics with a newly proposed highly efficient RG flow for IR physics, which has been shown to reproduce the traditional holographic correspondence.